Case report of the initial fingolimod therapy in children with multiple sclerosis
10.13699/j.cnki.1001-6821.2023.23.028
- VernacularTitle:多发性硬化儿童初次使用芬戈莫德治疗的病例分析
- Author:
Ran WEI
1
;
Xiu DONG
;
Chao-Yang CHEN
;
Yuan WU
;
Ying ZHOU
;
Ye WU
;
Yi-Min CUI
Author Information
1. 北京大学第一医院药学部,北京 100034
- Keywords:
fingolimod;
multiple sclerosis;
cardiac safety;
children
- From:
The Chinese Journal of Clinical Pharmacology
2023;39(23):3475-3478
- CountryChina
- Language:Chinese
-
Abstract:
A case series report was conducted to analyze the cases of children with multiple sclerosis(MS)who received fingolimod for the first time.Four Chinese children with MS were reported.A 9-year-old girl weighted 50 kg with low basal heart rate developed asymptomatic bradycardia.The other 3 children did not experience cardiac adverse reactions.Cardiac safety of the first dose of fingolimod in children with MS was also evaluated.We suggest that special attention should be paid to patients with slow basal heart rate,young age and low body weight.In order to promote its safe use at initiation,the monitoring time can be extended appropriately and night monitoring can be strengthened.
