Effects of high-fat diet intake on pharmacokinetics of moxifloxacin tablets in healthy Chinese volunteers
10.13699/j.cnki.1001-6821.2023.23.022
- VernacularTitle:高脂高热量饮食对中国健康受试者口服莫西沙星片药代动力学的影响
- Author:
Cai-Hui GUO
1
;
Na ZHAO
;
Wen-Rong SUN
;
Cong-Yang DING
;
Ben SHI
;
Xue SUN
;
Hao-Jing SONG
;
Bo QIU
;
Wan-Jun BAI
Author Information
1. 河北省人民医院 药学部,河北 石家庄 050051
- Keywords:
moxifloxacin tablet;
high-fat diet;
pharmacokinetics;
food effect;
liquid chromatography-tandem mass spectrometry
- From:
The Chinese Journal of Clinical Pharmacology
2023;39(23):3444-3448
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of fasting and high-fat diet on the pharmacokinetics of moxifloxacin in Chinese healthy adult subjects.Methods A single-center,randomized,open,single-dose trial design was used in this study,healthy subjects were assigned to receive single dose of moxifloxacin tablets 0.4 g in either fasting or high-fat diet state,and blood samples were taken at different time points,respectively.The concentrations of moxifloxacin in plasma were determined by liquid chromatography-tandem mass spectrometry.Results The main pharmacokinetic parameters of moxifloxacin in fasting state and high-fat diet states were as follows:Cmax were(2 286.09±802.64)and(1 963.33±474.99)ng·mL-1;t1/2 were(12.32±1.42)and(13.56±1.38)h;AUC0-twere(2.70±0.51)×104 and(2.60±0.55)×104 ng·mL-1·h;AUC0-∞ were(2.88±0.54)×104 and(2.85±0.63)×104 ng·mL-1·h;tmax were 1.50 and 2.00 h.After high-fat diet,the AUC was not significantly changed,Cmax was decreased by 14.12％,and tmax was indistinctively delayed(all P＞0.05).Conclusion Food had no effects on the absorption rate and degree of moxifloxacin.
