Association of polymorphisms in ADCY3 and NFIL3 with crohn's disease in Chinese individuals
10.13699/j.cnki.1001-6821.2019.08.005
- VernacularTitle:ADCY3和NFIL3基因多态性与中国人群克罗恩病易感性的研究
- Author:
Cai-Bin ZHANG
1
;
Hong ZHENG
;
Kang CHAO
;
Xia ZHU
;
Xiang GAO
;
Min ZHI
;
Pin-Jin HU
;
Min HUANG
;
Xue-Ding WANG
Author Information
1. 中山大学 药学院 临床药理研究所
- Keywords:
genetic polymorphism;
Crohn's disease;
inflammatory bowel disease;
susceptibility
- From:
The Chinese Journal of Clinical Pharmacology
2019;35(8):743-745,784
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between polymorphisms in ADCY3,C10orf55,IL18RAP,CARD9,NFIL3 and susceptibility for Crohn's disease in Chinese population. Methods A total of 192 patients with Crohn's disease and 192 healthy controls were enrolled. Polymorphisms of those genes was detected by Sequenom iPLEXTM Mass Assay platform. The relationship between gene polymorphisms and Crohn's disease susceptibility was analyzed. Results A polymorphism within ADCY3, rs6545800,was susceptibility loci for Crohn's disease. Compared with the TT genotype,CC + CT carriers were less likely to develop Crohn's disease (P = 0. 004,OR = 0. 45,95％ CI: 0. 26-0. 78) . There was a weak correlation between rs4743820 within the NFIL3 gene and the susceptibility to Crohn's disease. Compared with TT carriers,CC + CT carriers had a lower probability of experience Crohn's disease (P = 0. 056, OR = 0. 64, 95％ CI:0. 40-1. 02). In addition,we also found that CC + CT of rs4743820 carriers had a lower incidence of upper gastrointestinal lesions than TT carriers (P = 0. 017,OR = 0. 26,95％ CI: 0. 08-0. 83). Conclusion The polymorphisms in ADCY3 and NFIL3 gene are associated with susceptibility to Crohn's disease in Chinese population.
