Distribution of PEAR1 gene in Chinese patients with cardiovascular disease and healthy people
10.13699/j.cnki.1001-6821.2019.08.004
- VernacularTitle:血小板内皮聚集受体1基因多态性在中国心血管病患者和健康人中的分布差异
- Author:
Zhe WANG
1
;
Kun HU
;
Qian XIANG
;
Zhuo ZHANG
;
Yan-Jun GONG
;
Yi-Min CUI
Author Information
1. 北京大学第一医院 药剂科
- Keywords:
platelet endothelial aggregation receptor 1;
cardiovascular patients;
healthy population;
genetic polymorphism
- From:
The Chinese Journal of Clinical Pharmacology
2019;35(8):740-742
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the differences in distribution of platelet endothelial aggregation receptor 1 (PEAR1) between Chinese cardiovascular patients and healthy population. Methods This study used method of Sequenom Mass ARRY to detect differences in distribution of PEAR1 gene between Chinese cardiovascular patients and healthy population. Results A total of 203 patients with cardiovascular disease and 106 healthy volunteer were enrolled. Nineteen sites were detected and all of them are variants in PEAR1 locus. There is no statistical difference of distribution between patients and healthy volunteers(P > 0. 05). Conclusion PEAR1 gene have multiple polymorphic sites in Chinese people.
