Astragalus membranaceus and magnesium sulfate in gestational hypertension
10.13699/j.cnki.1001-6821.2019.08.003
- VernacularTitle:黄芪注射液联合硫酸镁注射液治疗妊娠高血压的临床研究
- Author:
Chang-Li KAN
1
;
Jiu-Min LI
;
Jing HOU
;
Xiang-Yang JING
;
Yan-Ju ZHU
;
Jin-Huan ZHANG
;
Yan-Wei GUO
;
Xue-Rong CHEN
Author Information
1. 承德医学院 附属医院 南院区 产科
- Keywords:
gestational hypertension;
magnesium sulfate;
astragalus membranaceus injection;
placenta growth factor;
matrix metalloproteinase-9
- From:
The Chinese Journal of Clinical Pharmacology
2019;35(8):737-739
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of magnesium sulfate in combination with astragalus membranaceus injection on the birth outcomes and expression of placenta tissue related gene of patients with gestational hypertension. Methods Seventy-six gestational hypertension patients were selected and randomly assigned to control group (n = 38) and treatment group (n = 38). The control group was given intravenous injection of 25％ magnesium sulfate (60 mL) once daily for 7 days,while the treatment group was give intravenous injection of astragalus (60 mL) on the basis of the control group once daily for 7 days. The changes of blood pressure,mean arterial pressure (MAP) and 24 h urine protein content of the two groups were compared. The placenta tissue of the two groups were collected after childbirth. Results After treatment,the total effective rates of the control group and the treatment group were86. 84％ (33/38) and 97. 37％ (37/38) ,respectively; the difference was statistically significant (P < 0. 05). There were significant differences between the control group and the treatment group in systolic blood pressure [(147. 21 ± 20. 01) mmHg vs (128. 46 ± 18. 43) mmHg],diastolic blood pressure [(90. 25 ± 15. 46) mmHg vs (73. 14 ± 14. 53) mmHg],MAP [(126. 76 ± 9. 65) mmHg vs (108. 15 ± 9. 57) mmHg] and the 24 h urine protein content [(2. 65 ±0. 87) g vs (1. 34 ±0. 79) g](P < 0. 05). Conclusion Magnesium sulfate combined with astragalus membranaceus injection can reduce the blood pressure of gestational hypertension patients,improve the pregnancy outcome; the action mechanism maybe related to the up-regulation of PLGF and MMP-9 protein expression of placenta tissue.
