Clinical trial of minocycline combined with metronidazole in treatment of generalized aggressive periodontitis
10.13699/j.cnki.1001-6821.2019.08.001
- VernacularTitle:米诺环素联合甲硝唑治疗广泛型侵袭性牙周炎的临床研究
- Author:
Li-Nan YU
1
;
Qi-Feng LUO
Author Information
1. 杭州口腔医院 修复科
- Keywords:
generalized aggressive periodontitis;
minocycline;
metronidazole;
cytokines
- From:
The Chinese Journal of Clinical Pharmacology
2019;35(8):731-733
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical efficacy and safety of minocycline combined with metronidazole in the treatment of extensive aggressive periodontitis. Methods A total of 82 generalized aggressive periodontitis(GAgP) patients were randomly assigned in control group (41 patients) and treatment group (41 patients). Control group received oral metronidazole tablet (0. 6 g) once daily for 7 days and injected with metronidazole gel (10 mg) metronidazole in the periodontal pocket once a week for 4 weeks. Treatment group were injected with 0. 5 g of minocycline ointment in the periodontal pouch,once a week for 4 weeks,on the basis of control group. The clinical efficacy,periodontal states,matrix metalloproteinase (MMP)-1,MMP-8, interleukin-17 (IL-17) and adverse reactions in both group were compared. Results After treatment,the total effective rates of the treatment group and the control group were 90. 24％ (37 cases/41 cases) and 70. 73％ (29 cases/41 cases) , the difference was statistically significant(P < 0. 05). After treatment, there were significant differences between the treatment group and the control group in the attachment loss (AL) [(2. 63 ± 0. 49) mm vs (3. 22 ± 0. 52) mm], the periodontal pocket depth (PD)[(2. 93 ± 0. 47) mm vs (3. 95 ± 0. 71) mm], the bleeding index (BI) [(1. 02 ± 0. 16) vs (2. 02 ± 0. 16) ],the plaque index (PLI) [(1. 05 ± 0. 22) vs (1. 15 ± 0. 36) ],MMP-1 [(1466. 16 ± 185. 13) ng·L-1 vs(1767. 40 ± 233. 57) ng·L-1 ],MMP-8 [(1334. 23 ± 173. 38) ng·L-1 vs (1726. 00 ± 168. 84) ng·L-1],IL-17 [(6. 04 ± 0. 65) pg·L-1 vs (9. 01 ± 1. 29) pg·μL-1](P < 0. 05). Both treatment group and control group had digestive tract reactions,neurological symptoms and rash,and the adverse drug reaction rates were 17. 07％(7 cases/41 cases) and 12. 19％(5 cases/41 cases) , respectively (P > 0. 05). Conclusion The clinical efficacy of minocycline combined with metronidazole in the treatment of GAgP is superior to metronidazole alone. The clinical effect is significant and the safety is better.
