Pathogenic characteristics and related risk factors of fungal infection after allograft liver transplantation
10.13699/j.cnki.1001-6821.2019.07.030
- VernacularTitle:同种异体肝移植术后真菌感染的病原菌特点及其相关危险因素分析
- Author:
Jun MA
1
;
Shao-Cheng LÜ
;
Jian-Tao KOU
;
Xian-Liang LI
;
Ji-Qiao ZHU
;
Qiang HE
;
Peng-Fei LI
Author Information
1. 首都医科大学 附属北京朝阳医院 肝胆外科
- Keywords:
liver transplantation;
fungal infection;
risk factor;
treatment
- From:
The Chinese Journal of Clinical Pharmacology
2019;35(7):703-705
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and related risk factors of early fungal infection in the patients after allograft liver transplantation. Methods We have retrospectively analyzed the clinical data of 19 patients with fungal infection in perioperative stage of liver allograft transplantation, analyzed pathogenic characteristics and related risk factors of fungal infection in patients. Results In our research, perioperative fungal infection rate of allograft liver transplantation was 6. 4％ (19 cases/298 cases) . All of fungal infection patients were single fungal infection, including 4 cases of pulmonary fungal infection and 15 cases of abdominal fungal infection. The most common pathogenic bacterias of fungal infection were Candida albicans, Candida tropicalis and Candida glabrata. Multivariate analysis showed that model of end-stage liver disease (MELD) score and acute rejection were independent risk factors of fungal infection (all P < 0. 05) . Conclusion Fungal infection is a common complication after allograft liver transplantation. MELD score and acute rejection may be the independent risk factors of fungal infection.
