Regulating effect of magnolol on lipid metabolism and immune response in high-fat diet-induced atherosclerotic rats
10.13699/j.cnki.1001-6821.2019.07.014
- VernacularTitle:厚朴酚对高脂饮食诱导的动脉粥样硬化大鼠脂代谢和免疫反应的调节作用
- Author:
Xiao-Wen ZHANG
1
;
Na FAN
;
Yao-Dong GUO
;
Xue-Jun WANG
;
Min CHENG
Author Information
1. 商洛学院 健康管理学院 护理系
- Keywords:
magnolol;
atherosclerosis;
lipid metabolism;
immune response
- From:
The Chinese Journal of Clinical Pharmacology
2019;35(7):647-650
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of magnolol on lipid metabolism and immune response in atherosclerotic rats induced by high-fat diet. Methods Rats were randomly divided into 5 groups: normal group, model group, and experimental-L, experimental-M, experimental-H groups, each group had 10 rats. Atherosclerotic rat model was induced by high-fat diet. Normal group and model group were given the same volume of normal saline. The experimental-L, experimental-M, experimental-H groups were given intraperitoneal injection of magnolol (10, 20 and 50 mg·kg-1, respectively) . The total cholesterol (TC) , interleukin-6 (IL-6) were detected by enzyme-linked immunosorbent assay. The number of CD44 positive cells was detected by flow cytometry.Results TC contents in normal group, model group and experimental-M, experimental-H groups were respectively (2. 51 ± 0. 44) , (9. 42 ± 0. 80) , (5. 43 ± 0. 60) , (3. 44 ± 0. 40) mmol · L-1; IL-6 levels in the 4 groups were (6. 06 ± 4. 03) , (33. 32 ± 7. 07) , (18. 76 ± 8. 78) , (10. 78 ± 4. 24) pg·m L-1; the CD44 positive cells in the 4 groups were 1. 40 ± 0. 08, 23. 51 ± 2. 12, 8. 71 ± 1. 52, 3. 60 ± 0. 60.Comparison between model group and normal group, the differences of the factors were significant (all P < 0. 01) ; comparison between experimental-M, experimental-H groups and model group, the differences of the factors were significant (all P < 0. 01) . Conclusion Magnolol ameliorates the abnormal lipids metabolism and alleviates inflammatory response in atherosclerotic rats induced by high-fat diet.
