Advances in regulation of pregnane X receptor-mediated drug transporter
10.13699/j.cnki.1001-6821.2018.20.021
- VernacularTitle:孕烷X受体介导的药物对转运体调控作用研究进展
- Author:
Dan-Dan ZHU
1
;
Yu-Qing XIONG
Author Information
1. 南昌大学 临床药理研究所
- Keywords:
drugs;
transporter;
pregnane X receptor
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(20):2469-2472
- CountryChina
- Language:Chinese
-
Abstract:
Pregnane X receptor (PXR) is a ligand-activated transcrip-tion factor that is abundantly expressed in hepatocytes , its ligand drugs can regulate drug transporters expression and activity via PXR -mediated signaling pathways , and thereby affect the drug disposition ,increase the risk of drug -drug interactions and adverse effects when combined with clinical medication.This paper systematically reviewed the current re-search progress and clinical correlation of drug regulatory transporters me-diated by PXR.
