Case analysis of individualized tacrolimus treatment on patient with nephrotic syndrome
10.13699/j.cnki.1001-6821.2018.19.029
- VernacularTitle:肾病综合征患者个体化应用他克莫司的病例分析
- Author:
Xiao-Dan ZHANG
1
;
Ran XIE
;
Yi-Min CUI
Author Information
1. 北京大学 第一医院 药剂科
- Keywords:
gene detection;
individuallized medication;
tacrolimus;
nephrotic syndrome;
therapeutic drug therapy
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(19):2345-2347
- CountryChina
- Language:Chinese
-
Abstract:
Objective To combine genotyping and therapeutic drug mo-nitoring ( TDM ) and to provide patients with reasonable treatment . Methods Clinical pharmacists were able to participate in the treatment of 1 patient with nephrotic syndrome ,analyze the causes of poor efficacy in the early stage of hospitalization , combine the genotyping result and remind the clinicians to adapt an appropriate drug dose ,or use a combi-nation of drugs to improve drug plasma concentration .It is recommended to monitor the plasma drug concentration of tacrolimus and develop ration-al use of immunosuppressant drugs .Results and conclusion The pa-tient's tacrolimus concentration quickly reached the standard and his condition improved.The patient was discharged.In clinical practice, pharmacists should combine the patient's diseases, medications, geno-types and other factors, with the use of drug interactions to increase plasma concentration of tacrolimus, save the patient's expenses, and fully use therapeutic drug monitoring and other means to improve the effectiveness of drug treatment and safety.
