Antitumor effects of specific antagonist of estrogen-related receptor alpha XCT790 on H22 tumor-bearing mice in vivo
10.13699/j.cnki.1001-6821.2018.19.021
- VernacularTitle:雌激素相关受体α特异性拮抗剂XCT790对H22荷瘤小鼠的体内抗肿瘤作用
- Author:
Li-Xiang YE
1
;
Guan-Yu RUAN
;
Bin-Hua DONG
;
Ya-Fang KANG
;
Fen LIN
;
Xiao-Dan MAO
;
Peng-Ming SUN
Author Information
1. 福建医科大学、福建省新药安全性评价中心
- Keywords:
estrogen related receptor alpha;
XCT790;
H22 liver cancer;
anti-tumor;
inhibition rate
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(19):2317-2319
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of specific antagonist of estrogen-related receptor alpha——XCT790 on tumor growth, weight, liver index(LI), spleen index(SI) and kidney index (KI) in the diffe-rent models of tumor -bearing mice.Methods The H22 ascitic and solid tumor-bearing mice models were established , then mice were ran-domized into five groups , including model group (20%DMSO), control group(cyclophosphamide:CTX 30 mg· kg -1), experimental -L,-M,-H groups(XCT790:2,4,6 mg· kg -1).The samples were obtained in 24 h after continuous intraperitoneal administration of drug or solvent to mice for 7 d.The ascitic volume and tumor weight were measured .The ratios of LI,SI,KI were calculated.Results The ascitic volume of mice in model group, control group,and experimental -L,-M,-H groups were (6.17 ±3.04),(3.28 ±1.62),(3.60 ±1.67),(4.67 ±2.57), (4.73 ±2.66 ) mL; comparing between control group , experimental -L group and model group,the differences were significant(all P<0.01).In H22 solid tumor -bearing mice, the tumor weight of mice in model group, control group, experimental -L,-M,-H groups were (2.53 ±0.39),(1.25 ±0.45),(1.27 ±0.61),(1.14 ±0.56),(1.24 ±0.39) g with significant difference com-pared with model group ( all P<0.05 ) .LI,SI and KI had no statistically significant differences in ascitic or solid tumor-bearing groups(all P>0.05 ) .Conclusion XCT790 had anti -tumor effect on H22 tumor-bearing mice without influences on ratios of liver ,spleen and kidney.
