Clinical trial of amitriptyline tablets combined with pinaverium bromide tablets in the treatment of diarrhea type irritable bowel syndrome
10.13699/j.cnki.1001-6821.2018.19.008
- VernacularTitle:阿米替林片联合匹维溴铵片治疗腹泻型肠易激综合征的临床研究
- Author:
Lei DAI
1
;
Ming-Xian CHEN
;
Rui FU
;
Liang XIA
;
Bao-Ying FEI
;
Tang-Biao SHEN
Author Information
1. 浙江省立同德医院 消化内科
- Keywords:
amitriptyline;
pinaverium bromide;
irritable bowel syndrome with diarrhea;
combined treatment
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(19):2269-2272
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy of pinaverium bromide alone or in combination with amitriptyline in the treatment of diarrhea type irritable bowel syndrome ( IBS-D).Methods One hundred and twenty-five patients with IBS -D,aged 18 -65 years,in our hospital from June 2013 to June 2016 were randomly divided into control group (63 cases,treated with pinaverium bromide 50 mg,tid) and treatment group (62 cases, on the basis of control group ,treated with amitriptyline 25 mg,qd).The total effective rate,the stool property and state,and the quality of life were assessed by IBS -bowel symptom severity scale (IBS-BSS),IBS-defecation state questionnaire ( IBS-DSQ) and the IBS-quality of life questionnaire (IBS-QOL) before and 4 weeks after the treatment respectively.Results After treatment,the IBS-BSS efficacy of the control group and the treatment group were 61.90%(39 cases/63 cases) and 85.48%(53 cases/62 cases), respectively, and the di-fference were statistically significant ( P<0.01 ).Total IBS-BSS scores of the control group and the treatment group were (166.32 ±72.75 ), (112.98 ±81.84 )point,respectively;which was significantly decreased in the treatment group (P<0.01).The IBS-DSQ effective rates of the control group and the treatment group were 71.43%(45 cases/63 cases) and 91.94%(57 cases/62 cases),respectively;which was significantly increased in the treatment group than that in the control group (P<0.01).Moreover,the total IBS-QOL integrals were statistically increased in the two groups , with the treatment group more pronounced.Conclusion Pinaverium bromide in combination with amitriptyline could effectively relieve bowel symptoms,improve the stool property and the defecation frequency and thus improve their quality of life ,which has a certain clinical application value .
