Difference distribution of glycoprotein Ⅱb/Ⅲa receptor exon polymorphisms between Chinese cardiovascular patients and healthy population
10.13699/j.cnki.1001-6821.2018.19.001
- VernacularTitle:糖蛋白Ⅱb/Ⅲa受体外显子基因多态性在中国心血管病患者和健康志愿者中的分布差异
- Author:
Zhuo ZHANG
1
;
Qian XIANG
;
Yan-Jun GONG
;
Kun HU
;
Qiu-Fen XIE
;
Zi-Ning WANG
;
Yi-Min CUI
Author Information
1. 北京大学 第一医院药剂科
- Keywords:
glycoprotein Ⅱb/Ⅲa;
cardiovascular patient;
healthy Chinese population;
genetic polymorphisms
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(19):2245-2247,2251
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the differences in distribution of Glycoprotein (GP)Ⅱb/Ⅲa receptor exon polymorphisms between Chi-nese cardiovascular patients and healthy population .Methods Based on our previous study of healthy volunteers , this study used the method of Sequenom Mass ARRAY?to detect the exon mutation sites of ITGI2B and ITGB3 which encoding GPⅡb/Ⅲa receptor and analyzed the differences in distribution between the two populations .Results Eighteen sites were detected.Three variants in the ITGA2B locus and fifteen variants in the ITGB3 locus were identified.The linkage relationships between single nucleotide polymorphisms (SNPs) in cardiovascular patients and healthy population were similar. The genotypes of ITGB3 rs112188890 (P<0.001), rs11871447 ( P <0.001 ), rs4634 ( P <0.05 ), and rs70940817 ( P<0.001 ) were significantly different between cardiovas-cular patients and healthy population.Conclusion There are multiple polymorphic sites in the exons of ITGI2B and ITGB3 in Chinese population.
