A Case of Skin Sclerosis Associated with Docetaxel Chemotherapy for Non-Small Cell Lung Cancer.
10.4078/jrd.2013.20.3.198
- Author:
Jae Hyung NAM
1
;
Jong Joo MOON
;
June Hyuk LEE
;
Sung Woo PARK
;
An Soo JANG
;
Do Jin KIM
;
Chan Hong JEON
;
Eun Suk KOH
Author Information
1. Division of Respiratory-Allergy Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea. junehyuk@schmc.ac.kr
- Publication Type:Case Report
- Keywords:
Docetaxel;
Scleroderma;
Lung cancer;
Adverse effect
- MeSH:
Antibodies;
Biopsy;
Carboplatin;
Carcinoma, Non-Small-Cell Lung;
Carcinoma, Squamous Cell;
Collagen;
Dermis;
Diuretics;
Edema;
Female;
Foot;
Glycogen Storage Disease Type VI;
Humans;
Knee;
Leg;
Lung Neoplasms;
Lymphocytes;
Penicillamine;
Pigmentation;
Prednisolone;
Sclerosis;
Serologic Tests;
Skin;
Taxoids
- From:Journal of Rheumatic Diseases
2013;20(3):198-201
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 64-year-old woman was diagnosed with non-small cell lung cancer. Her disease was stage 4 (T2N2M1) with squamous cell carcinoma. She had been treated with docetaxel and carboplatin. After a completion of 11 cycle of chemotherapy, edema appeared on both feet and had spread rapidly up to the pretibial area without response to diuretics. Sclerotic changes and pigmentation followed but both knees and other parts of the body were spared. There was no evidence of vascular occlusions. On serologic tests, antinuclear, anti-centromere, and anti-topoisomerase I antibodies were all negative. A skin biopsy revealed diffuse infiltration of lymphocytes and discretely thickened collagen bundles in the superficial dermis. After discontinuing docetaxel chemotherapy, she was treated with prednisolone and D-penicillamine and sclerotic changes on the lower legs were improved.
