Research status of laboratory tests for patients with direct oral anticoagulants
10.13699/j.cnki.1001-6821.2018.10.033
- VernacularTitle:直接口服抗凝药患者实验室检测的研究现状
- Author:
Zhe WANG
1
;
Qiu-Fen XIE
;
Qian XIANG
;
Yi-Min CUI
Author Information
1. 北京大学第一医院药剂科
- Keywords:
dabigatran;
rivaroxaban;
apixaban;
edoxaban;
direct oral anticoagulant;
laboratory testing
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(10):1253-1256
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,the use of direct oral anticoagulants (DOACs) have been gradually accumulated in clinical practice.In specific cases,the DOACs blood concentration of patients are needed to be clearly defined in order to assist in further diagnosis and treatment.Therefore,through the study of literature retrieval of DOACs laboratory test at home and abroad,we intended to explore detection method of four kinds of DOACs (dabigatran,rivaroxaban,apixaban and edoxaban).Meanwhile we also discussed the use of DOACs detection and its effect on coagulation function detection in emergency or during the perioperative period.Finally,the results turned out that patients with dabigatran can detect the blood concentration by activated partial thromboplastin time,diluted thrombin time and ecarin clotting time.Factor Xa activity assay can be used for patients taking direct a factor Xa inhibitor,and high sensitivity of prothrombin time detection are especially suitable for rivaroxaban patients.
