Expression of phospholipase A2 in peritoneal fluid of patients with endometriosis and its clinical significance
10.13699/j.cnki.1001-6821.2018.10.032
- VernacularTitle:子宫内膜异位症患者腹腔液中磷脂酶A2表达及其临床意义
- Author:
Qiu-Fang BAO
1
;
Jun-Ying QU
Author Information
1. 福建医科大学附属第一医院妇产科
- Keywords:
hospholipase A2;
endometriosis;
inflammation
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(10):1250-1252
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression and clinical significance of phospholipase A2 (PLA2) expression in celiac fluid of endometriosis patients and its clinical significance.Methods Forty three cases of endometriosis patients without chronic pelvic inflammatory disease were selected as treatment group (n =43),30 cases of patients with ovarian benign teratoma were selected as control group (n =30).The levels of secreted phospholipase A2 (sPLA2) in peritoneal fluid of two groups were compared,to determine the tissue localization of cytosolic phospholipase A2 (cPLA2),and to compare the expression of cPLA2 in patients with different stages of endometriosis.Results The levels of sPLA2 in peritoneal fluid of treatment group and control group were 578.4,544.4 ng· L-1,with significant difference (P ＜ 0.05).The cPLA2 is mostly located on cytoplasm of glandular epithelial cells,blood vessel endothectopic endometrium.The levels of cPLA2 in endometriosis group in Ⅲ-Ⅳ stage was (0.70 ± 0.30) ng · L-1,significantly higher than that of Ⅰ-Ⅱ stage,which was (0.27 ±0.19) ng · L-1 (P ＜0.05).Conclusion Both the levels of sPLA2 and cPLA2 are highly expressed in endometriosis patients,with the progress of the disease,the degree of PLA2 expression increased.PLA2 may play an important role in the activation of endometriosis.
