Drug use research of patients with coronary heart disease and methodological evaluation
10.13699/j.cnki.1001-6821.2018.10.030
- VernacularTitle:冠心病患者药物使用研究与方法学评价
- Author:
Ming-Yang SUN
1
;
Ying-Ying YAN
;
Suo-Di ZHAI
Author Information
1. 北京大学第三医院药剂科
- Keywords:
coronary heart disease;
drug therapy;
literature research;
database research;
pharmacoepidemiological
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(10):1243-1245
- CountryChina
- Language:Chinese
-
Abstract:
Objective To report the preliminary results of drug use in patients with coronary heart disease,and to compare the differences of research results and methodologies between literature research and database research.Methods PubMed,EMbase,Cochrane Library,Wanfang data base,CNKI and CBM,were searched to collect all related literatures from beginning to November 28,2015.Data extracted from each individual study were analyzed using Excel 2011;patients with coronary heart disease from the database of a real word study were screened,and the drug use of patients with coronary heart disease was analyzed using SPSS 21.0 and Excel 2011.Results The literature research showed that the utilization rates of antiplatelet drugs,β-blocker,statins,angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blocker (ARB) were 90.62％,65.38％,73.94％,43.56％ and 19.95％ respectively;the database analysis showed that the utilization rate of antiplatelet drugs,β-blocker,statins,ACEI and ARB were 77.40％,53.60％,68.60％,27.00％ and 26.00％,respectively.Compared with database research,literature research has the characteristics of large sample size,low cost and fast acquisition.Conclusion There are both advantages and disadvantages in all the research methods of drug epidemiology,and literature researches can be used for pharmacoepidemiological study if there is enough original researches.
