Evaluating the effect of moisturizing intestine to relaxing the bowels of Angelica's different extracted parts with Fuzzy Matter-element model based on variation coefficient weight
10.13699/j.cnki.1001-6821.2018.10.016
- VernacularTitle:基于变异系数的模糊物元模型评价当归不同提取部位润肠通便的效果
- Author:
Guo-Jin REN
1
;
Shun-Juan ZHU
;
Peng-Fei XIA
;
Qian LUO
;
Ling-Xia WEI
;
Dang YANG
;
Lei ZHAO
Author Information
1. 甘肃中医药大学药学院
- Keywords:
Angelica's different extracted parts;
loosening bowel to relieve constipation;
fuzzy matter-element model;
variation coefficient weight
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(10):1191-1194
- CountryChina
- Language:Chinese
-
Abstract:
Objective To screen the effective parts of loosening bowel and relieving constipation in mice from different extracted parts of Angelica and to investigate the utilization of fuzzy matter-element model in evaluating the effect of moisturizing intestine to relaxing the bowels of Angelica's different extracted parts.Methods Kunming mice were randomly divided into 11 groups,including normal group,model group (constipation),positive control group (Nongsuo Danggui Wan and Runchang Wan:20 μL · g-1),medicated group consisted by 7 different extracted parts of Angelica (3.4 g · kg-1 Angelica herbs).The constipation model was formed by the compound difenoxate solution 5.0 mg · kg-1 and finished after 30 min.We used the first defecation time as well as the dark stool points in 6 h,the weight of stools,the pushing rate of intestine and intestinal moisture as detection index and then using fuzzy matter-element model on variation coefficient weight to evaluate the comprehensive effect of different extract parts of Angelica.Results Time of first black stool discharge as well as the dark stool points in 6 h,the weight of stools,the pushing rate of intestine and intestinal moisture in model group were (241.90 ± 48.10) min,(9.00 ± 5.40) count,(149.10 ± 86.80) mg,(48.90 ± 16.50) ％,(1.45 ± 0.16) g,respectively.The 70％ ethanol impregnation part (part 2) on the factors were (172.60 ± 40.70) min,(17.30 ± 4.50) count,(223.70 ± 63.40) mg,(73.70 ± 13.10) ％,(1.71 ± 0.18) g,respectively.The difference between part 2 and model group was statistically significant in the factors (P ＜0.05 or P ＜0.01).Combining with the result of the value of Euclid approach degree,the maximum is 0.71 (part 2:70％ alcohol impregnation part).Conclusion The 70％ alcohol impregnation part is the effective part of loosening bowel to relieve constipation in mice.The method and model can be used to objectively evaluate the effect of moisturizing intestine to relaxing the bowels of Angelica' s different extracted parts.
