Influencing factors of lower respiratory infected children with diarrhea and thrush
10.13699/j.cnki.1001-6821.2018.10.001
- VernacularTitle:儿童下呼吸道感染并存腹泻和鹅口疮的影响因素分析
- Author:
Sai-Nan SUN
1
;
Wen-Jing GU
;
Xin-Xing ZHANG
;
Yin-Ying REN
;
Lin DING
;
He-Ting DONG
;
Zheng-Rong CHEN
;
Yong-Dong YAN
;
Wei JI
Author Information
1. 苏州大学附属儿童医院呼吸科
- Keywords:
lower respiratory tract infection;
diarrhea;
thrush;
influence factor
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(10):1131-1135
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate influence factors of diarrhea,thrush and multi-system damage in hospitalized children with lower respiratory infection (LRI).Methods A total of 9135 children with LRI who were hospitalized in our hospital were divided into four groups according to whether they had diarrhea and/or thrush:A (simple LRI group) has 7716 children,B (LRI complicated with diarrhea group) has 1057 children,C (LRI complicated with thrush group) has 200 children,D (LRI complicated with diarrhea and thrush group) include 162 children.All clinical data of four groups were collected and retrospectively reviewed.Results Infants less than six months of the group B,C and D had the highest incidence,followed by babies from six months to one year old,the lowest was the group that over the age of five.The incidence of group B and D was highest in winter.The incidence of in hospital or out of hospital for more than 14 d in group D was higher than that for less than 14 d.The incidence of premature infants in group C and group D were 3.70％ and 3.90％,higher than 2.10％ and 1.65％ of the full-term infants.The incidence of children with atopic in group B and D was 16.83％ and 3.00％,which was higher than 10.70％ and 1.57％ in children with non-atopic.The incidence of severe children in group B,C and D were 15.97％,3.92％ and 4.20％,which was significantly higher than 11.39％,2.12％ and 1.68％ of the normal patients;and 15.29％,4.00％,4.09％ in children who use antibiotics for more than 14 d which was higher than 10.44％,1.64％,1.07％ for less than 14 d.The proportion of multiple antibiotic user in group D was 2.16％,which was significantly higher than 1.12％ of the single antibiotic user.The rate of hormone application in group B and D was 13.25％ and 2.07％,which was significantly higher than 9.98％ and 1.49％ of non-hormone users.The levels of CD3 + in group B,C,D were significantly lower than that in group A,and the percentage of CD3 + CD8 + was below the normal reference value.The percentages of CD3-CD19 + and CD19 + CD23 + in four groups were significantly higher than the normal reference value.Conclusion The high incidence of diarrhea and/or thrush in pediatric patients with LRI was associated with some factors,including winter admission,premature,atopic,long course of hospital and out of hospital,severe disease,long-term or joint use of antibiotic,hormone therapy or low level of CD3 +.In clinical practice,reasonable and positive intervention and immune regulation in the early stage of disease will help to reduce the occurrence of diarrhea and/or thrush in children with LRI,promote disease recovery,reduce the use of medical resources and cases of severe,critical and refractory.
