Risk factors for the short-term prognosis of anti-N-methyl-D-aspartic acid receptor encephalitis in children
10.13699/j.cnki.1001-6821.2018.09.031
- VernacularTitle:儿童抗Ⅳ-甲基-D-天门冬氨酸受体脑炎近期预后危险因素分析
- Author:
Xian-Ting XIE
1
;
Chao-Yang CHEN
;
Hai-Sheng YOU
;
Zong-Yan LIU
;
Ying ZHOU
;
Yi-Min CUI
Author Information
1. 北京大学第一医院药剂科
- Keywords:
anti-N-methyl-D-aspartic acid receptor;
immunotherapy;
influence factor;
child
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(9):1119-1121
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the risk factors of the short-term prognosis of anti-N-methyl-D-aspartic acid (anti-NMDAR) encephalitis.Methods The clinical data of 66 children with anti-NMDAR encephalitis was analyzed retrospectively,and the scores of modified Rankin scale (mRS) were used before and after treatment.According to the treatment results,the children with mRS less than or equal to 2 points were used as treatment group,those with mRS score more than 3 points were set as the control group.Single factor and multiple factor Logistic regression analysis were used to analyze the risk factors of poor prognosis.Results Of the 66 cases,39 had good prognosis and 27 had poor prognosis.The results of single factor analysis showed that age,days of hospitalization,epilepsy,dyskinesia,mRS scores score were associated with poor prognosis.Multiple factor Logistic regression analysis showed that age,epileptic seizures,and mRS scores before treatment were independent risk factors for the short-term prognosis of anti-NMDAR encephalitis.Conclusion Patients with anti-NMDAR encephalitis have small age,seizures and high mRS scores before treatment,which may predict poor prognosis in the near future.
