Influence of combination of external prostaglandin and narrow band ultraviolet B on skin melanin and tyrosinase level in Guinea pigs with vitiligo
10.13699/j.cnki.1001-6821.2018.09.027
- VernacularTitle:外用前列腺素联合窄谱中波紫外线对白癜风豚鼠模型黑色素及酪氨酸酶水平的影响
- Author:
Ya-Ning JIAO
1
;
Jing-Xia WANG
;
Yun ZHANG
;
De-Mei WU
;
Ke CHEN
;
Nan YU
;
Min JIANG
;
Li XIA
;
Li LIANG
;
Jia-Wei WANG
;
Ju-Fei WANG
Author Information
1. 宁夏医科大学总医院皮肤科
- Keywords:
vitiligo;
prostaglandin;
narrow band ultraviolet B;
melanin;
tyrosinase
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(9):1105-1107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of combination of external prostaglandin and narrow band ultraviolet B (NB-UVB) on skin melanin and tyrosinase level in models with vitiligo.Methods Guinea pigs models with vitiligo were produced by 3％ hydroquinone cream.And then all the animal models were randomly divided into six groups according to the weight:normal group,model group,control group,medication alone group,light alone group and combination group.Normal group and model group were not treated.Control group was used the same amount of vaseline,2 times per day;the 0.25 mg · mL-1 dipropionazone tincture skin smear in medication alone group,2 times per day,stay on 2 months;the NB-UVB irradiation treatment instrument was exposed to 1 J · cm-1 at about 20 cm from the skin of the white spot,and the wavelength was 310 ～315 nm in light alone group,and once every other day,stay on 2 months;combination group,topical prostaglandina combination NB-UVB irradiation,frequency,method and time same to medication alone group and light alone group.After administration,the observation of vitiligo guinea pig skin tissue morphology and melanin distribution in the light microscope.Results The percentage of melanin hair follicles in model group,control group,medication alone group,light alone group and combination group were (37.50 ± 20.43) ％,(53.33 ± 14.38) ％,(55.00 ± 16.12) ％,(46.67 ± 19.66)％,(71.67 ± 7.53)％,respectively.The combined group is compared to the model group,the difference is significant in statistics (P ＜ 0.05).But comparison between control group,medication alone group,light alone group and model group,the difference were not significant in statistics (all P ＞ 0.05).Conclusion Combination of external prostaglandins and NB-UVB have some effect on vitiligo treatment.
