Locally delivered antioxidant gel as an adjunct to nonsurgical therapy improves measures of oxidative stress and periodontal disease.
10.5051/jpis.2013.43.3.121
- Author:
Rampalli Viswa CHANDRA
1
;
Gorremuchu SRINIVAS
;
Aileni Amarender REDDY
;
Bavigadda Harish REDDY
;
Chakravarthy REDDY
;
Sripriya NAGARAJAN
;
Anumala NAVEEN
Author Information
1. Department of Periodontics, SVS Institute of Dental Sciences, Mahabubnagar, India. viswachandra@hotmail.com
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Antioxidants;
Oxidative stress;
Periodontitis
- MeSH:
Antioxidants;
Carotenoids;
Deoxyguanosine;
Flow Cytometry;
Gingival Crevicular Fluid;
Gingivitis;
Inflammation;
Oxidative Stress;
Periodontal Diseases;
Periodontal Pocket;
Periodontitis;
Reactive Oxygen Species;
Root Planing;
Salicylamides
- From:Journal of Periodontal & Implant Science
2013;43(3):121-129
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The present study has two aims; firstly, it attempts to verify the presence of oxidative stress by estimating the reactive oxygen species (ROS) levels in periodontal pockets > or =5 mm as compared to controls. The second aim is to evaluate the effect of lycopene as a locally delivered antioxidant gel on periodontal health and on the gingival crevicular fluid (GCF) levels of 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative injury. METHODS: Thirty-one subjects participated in this study. In the pretreatment phase, the ROS levels in pockets > or =5 mm were measured by flow cytometry. Three sites in each subject were randomly assigned into each of the following experimental groups: sham group, only scaling and root planing (SRP) was done; placebo group, local delivery of placebo gel after SRP; and lycopene group, local delivery of lycopene gel after SRP. Clinical parameters included recording site-specific measures of GCF 8-OHdG, plaque, gingivitis, probing depth, and clinical attachment level. RESULTS: The gel, when delivered to the sites with oxidative stress, was effective in increasing clinical attachment and in reducing gingival inflammation, probing depth, and 8-OHdG levels as compared to the placebo and sham sites. CONCLUSIONS: From this trial conducted over a period of 6 months, it was found that locally delivered lycopene seems to be effective in reducing the measures of oxidative stress and periodontal disease.
