Correlation analysis between immune dysfunction and inflammation in patients with sepsis
10.13699/j.cnki.1001-6821.2018.09.011
- VernacularTitle:脓毒症患者免疫功能障碍与炎症的相关性分析
- Author:
Jie LIU
1
;
Hu-Nian LI
;
Xu ZHAO
;
Jun-Xing SHI
;
Yong BAI
;
Guang-Qing HUANG
Author Information
1. 湖北医药学院附属人民医院重症医学科
- Keywords:
sepsis;
immune function;
inflammatory factor;
correlation;
Acute Physiology and Chronic Health Evaluation Ⅱ
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(9):1045-1047
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate and analysis the correlation between immune dysfunction and inflammation in patients with sepsis.Methods From February 2013 to May 2017,80 cases of sepsis patients in our hospital intensive care unit were selected as the treatment group,and the other 80 healthy people were enrolled as control group.The inflammatory factors,such as interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α)were deternied by enzyme linked immunosorbent assay.The immune function index (CD4 + and CD8 +) were detected by flow cytometry.The correlation were analyzed.Results The contents of serum IL-6 and TNF-α in the treatment group were (85.73 ± 15.34),(58.04 ± 9.11) pg · mL-1,respectively,which were significantly higher than (12.33 ± 8.24),(17.49 ± 8.76) pg · mL-1 in the control group with significantly(all P ＜ 0.05).The CD4 + and CD8 + values in the treatment group were (48.71 ± 11.16)％ and (22.11 ± 11.09)％,and the control group were (35.75 ± 11.31)％ and(28.83 ± 11.36)％ respectively.The difference comparison between the two groups were statistically significant (all P ＜ 0.05).Among the 80 patients in the treatment group,Pearson correlation analysis showed that IL-6 and TNF-α were positively correlated with CD4 + (all P ＜0.05),but negatively correlated with CD8 + (P ＜ 0.05).Logistic regression analysis showed that IL-6,TNF-α,CD4 + and CD8 + were the major independent risk factors for affecting Acute Physiology and Chronic Health Evaluation (APAHCE) Ⅱ score (all P ＜ 0.05).Conclusion There are inflammatory reaction and immune dysfunction in sepsis patients that they can interact with each other and affect the APAHCE Ⅱ score.
