Clinical trial of metoprolol tartrate tablet in combination with simvastatin tablet in the treatment of coronary heart disease with angina pectoris
10.13699/j.cnki.1001-6821.2018.08.003
- VernacularTitle:酒石酸美托洛尔片联合辛伐他汀片治疗冠心病心绞痛的临床研究
- Author:
Ying-Ju FU
1
;
Zhi-Ning LIU
;
Yu-Xin SONG
Author Information
1. 唐山工人医院 急诊内科
- Keywords:
coronary heart disease with angina pectoris;
metoprolol tartrate tablet;
simvastatin tablet
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(8):922-925
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy and safety of metoprolol tartrate tablet in combination with simvastatin tablet in the treatment of coronary heart disease with angina pectoris.Methods A total of 96 patients with coronary heart disease and angina were randomly divided into control group and treatment group (n =48 cases).The control group received oral administration of metoprolol tartrate 12.5 mg twice daily.The treatment group received oral administration of simvastatin 10 mg once daily on the basis of the control group.Both groups were treated for 3 months.Clinical efficacy,serum vascular endothelial growth factor (VEGF),matrix metalloproteinases inhibitory factor 1 (TIMP-1),matrix metalloprotei-nase-2 (MMP-2) and matrix metalloproteinases-9 (MMP-9),angina duration,number of episodes and adverse drug reactions were compared between the two groups.Results After treatment,total effective rate in the treatment group and control group was 95.83％ (46 cases/48 cases) and 81.25％ (39 cases/48 cases),with significant difference (P ＜ 0.05).There were significant differences between the treatment group and the control group in the levels of serum VEGF [(79.47 ±9.21) ng· L-1 vs (67.88 ±7.82) ng· L-1],TIMP-1 [(331.04±41.02) μg· L-1 vs (219.94±26.04) μg· L-1],MMP-2 [(125.54±15.15) μg· L-1 vs (185.67 ±33.16) μg · L-1],MMP-9 [(178.62 ±24.82) μg · L-1 vs (247.91 ±26.34) μg · L-1],duration of angina pectoris [(4.11 ±0.62) min vs (5.45 ±O.72) min] and frequency of angina pectoris [(3.19 ±0.38) times vs (4.50 ± 0.51) times per week] (P ＜ 0.05).The adverse drug reactions in the treatment group and control group were dizziness,epigastric discomfort,sinus bradycardia,and the incidences of adverse reactions in treatment group and control group were 8.33％ (4 cases/48 cases) and 12.50％ (6 cases /48 cases),without significant difference (P ＞0.05).Conclusion Metoprolol tartrate tablet in combination with simvastatin tablet exerts higher clinical efficacy than metoprolol tartrate alone in the treatment of coronary heart disease with angina pectoris,while providing a good safety profile.
