Clinical trial of ambroxol injection combined with ciprofloxacin injection in the treatment of lower respiratory tract infection associated with drug-resistant Pseudomonas aeruginosa
10.13699/j.cnki.1001-6821.2018.08.001
- VernacularTitle:氨溴索注射液联合环丙沙星注射液治疗铜绿假单胞菌耐药下呼吸道感染的临床研究
- Author:
Qian-Qian FANG
1
;
Shi-Bao FU
;
Qiu-Ting WANG
;
Song YANG
;
Wen-Bin XU
;
Ying-Shan FU
Author Information
1. 海南医学院第二附属医院体检科
- Keywords:
ambroxol injection;
ciprofloxacin injection;
drug-resistant Pseudomonas aeruginosa;
lower respiratory tract infection;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(8):915-918
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of ambroxol injection combined with ciprofloxacin injection in the treatment of lower respiratory tract infection associated with drug-resistant Pseudomonas aeruginosa.Methods A total of 68 patients with lower respiratory tract infection associated with drug-resistant Pseudomonas aeruginosa were randomly divided into control and treatment groups with 34 cases per group.Control group was treated with cefoperazone sodium and sulbactam sodium 3 g per time,tid,intravenous infusion.Treatment groups was treated with ambroxol 30 mg per time,tid,nebulization inhalation + ciprofloxacin 0.6 g per time,qd,intravenous drip,on the basis of control group.Two groups were treated for 14 d.The clinical efficacy,bacterial clearance rate and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of the treatment and control groups were 91.18％ (31 cases / 34 cases) and 70.59％ (24 cases / 34 cases),the bacterial clearance rates of the treatment and control groups were 94.12％ (32 cases / 34 cases) and 76.47％ (26 cases / 34 cases),the differences were statistically significant (all P ＜ 0.05).The adverse drug reactions of treatment group were gastrointestinal reaction and sudden elevation of blood pressure,which in control group were gastrointestinal reaction and fever.The incidences of adverse drug reactions in treatment and control groups were 20.59％ and 14.71％ without significant difference (P ＞0.05).Conclusion Ambroxol injection combined with ciprofloxacin injection has definitive clinical efficacy in the treatment of lower respiratory tract infection associated with drug-resistant Pseudomonas aeruginosa,which can significantly increase the bacterial clearance rate,without increasing the incidence of adverse drug reactions.
