Systematic review of the effect of coenzyme Q10 on antioxidant capacity while focused on evaluation of claims for health functional food.
10.4163/jnh.2013.46.3.218
- Author:
Ji Yeon KIM
1
;
Sewon JEONG
;
Ju Eun PAEK
;
Joohee KIM
;
Jin Sook KWAK
;
Yoon Jung LEE
;
Tae Seok KANG
;
Oran KWON
Author Information
1. Department of Food Science and Technology, Seoul National University of Science and Technology, Seoul 139-743, Korea.
- Publication Type:Original Article
- Keywords:
systematic review;
coenzyme Q10;
antioxidant;
health functional food;
re-evaluation
- MeSH:
Asian Continental Ancestry Group;
Functional Food;
Humans;
Korea;
Ubiquinone;
United States Food and Drug Administration
- From:Journal of Nutrition and Health
2013;46(3):218-225
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Although the functional ingredient has been evaluated by the Korea Food and Drug Administration (KFDA) based on scientific evidence, the levels of scientific evidence and consistency of the results might vary according to emerging data. Therefore, periodic re-evaluation may be needed for some functional ingredients. In this study, we re-evaluated scientific evidence for the antioxidant activity of coenzyme Q10 as a functional ingredient in health functional food. Literature searches were conducted using the Medline and Cochrane, KISS, and IBIDS databases for the years 1955-2010 with the search term of coenzyme Q10 in combination with antioxidant. The search was limited to human studies published in Korean, English, and Japanese. Using the KFDA's evidence based evaluation system for scientific evaluation of health claims, 33 human studies were identified and reviewed in order to evaluate the strength of the evidence supporting a relation between coenzyme Q10 and antioxidant activity. Among 33 studies, significant effects for antioxidant activities were reported in 22 studies and their daily intake amount was 60 to 300 mg. Based on this systematic review, we concluded that there was possible evidence to support a relation between coenzyme Q10 intake and antioxidant activities. However, because inconsistent results have recently been reported, future studies should be monitored.
