Comparison of three platelet function tests on patients underwent percutaneous coronary intervention

VernacularTitle:3种方法检测经皮冠状动脉介入治疗术后患者氯吡格雷的药效学
Author: Xun ZHAO ¹ ; Qian XIANG ; Yan-Jun GONG ; Shu-Qing CHEN ; Kun HU ; Shuang ZHOU ; Yi-Min CUI
Author Information

1. 北京大学第一医院药剂科
Keywords: platelet reactivity; thrombelastography; light transmission aggregometry; VerifyNow
From: The Chinese Journal of Clinical Pharmacology 2018;34(7):875-877
CountryChina
Language:Chinese
Abstract: Objective To compare the ability and influence factors of three platelet function tests:light transmission aggregometry (LTA),thrombelastograph (TEG) and VerifyNow.Methods A total of 174 patients underwent percutaneous coronary intervention (PCI) and platelet function test were enrolled.Platelet function were tested by LTA,TEG and VerifyNow.Results Patients were found to be high platelet reactivity (HPR) by LTA (56.64％,64 cases/113 cases),TEG(60.38％,32 cases/52 cases),VerifyNow (17.24％,15 cases /87 cases).There were no significant differences observed between TEG and LTA (P ＞0.05).VerifyNow identified lower HPR proportion compared with TEG and LTA (all P ＜ 0.001).Conclusion Compared with LTA and TEG,VerifyNow identified lower HPR proportion and may overestimate the effectiveness of clopidogrel.We will follow the patients to study the predictive capability of three tests.