In vitro synergistic interactions between palmatine and commonly used antibiotics
10.13699/j.cnki.1001-6821.2018.07.026
- VernacularTitle:黄藤素与临床常用抗菌药物体外联合抗菌作用研究
- Author:
Yun LI
1
;
Yuan L(U)
;
Jian LIU
;
Feng XUE
;
Wei-Wei YANG
;
Jia ZHANG
;
Ai-Lian SHAN
Author Information
1. 北京大学第一医院临床药理研究所
- Keywords:
palmatine;
linezolid;
levofloxacin;
in vitro activity;
synergy
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(7):821-823
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate in vitro synergy between palmatine and commonly used antibiotic against main clinical isolated strains in recent three years.Methods All of 118 strains isolated in recent three years and 2 standard strains were studied.Minimal inhibition concentrations (MIC) were tested by agar dilution method and combination effects were measured by checkerboard method.Results Palmatine showed moderate in vitro activity against Staphylococcus.Synergy was detected with palmatine in combination with levofloxacin against gram-positive and negative strains,though synergistic rate less than 20％.Synergy was not show between palmatine and linezolid.Additive effect was found widely between palmatine and two agents against almost all tested species.Conclusion The results of in vitro synergy tests may be different sometimes on account of various strains,methods,etc.So,more deeper understanding of action mechanism of traditional Chinese medicine and correlation between in vitro test and clinical outcomes will help medical to select antibiotic more suitablly.
