Expression of Occludin protein in cervical cancer and its clinical significance
10.13699/j.cnki.1001-6821.2018.07.023
- VernacularTitle:紧密连接蛋白在人宫颈癌组织中的表达及其临床意义
- Author:
Bin ZHANG
1
;
Li-Hong CHEN
;
Yi-Lu ZOU
;
Qiu-Fang BAO
Author Information
1. 福建医科大学附属第一医院妇产科
- Keywords:
Occludin;
cervical cancer;
clinical characteristics
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(7):812-814
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of Occludin in human cervical cancer and its clinical significance.Methods Forty patients with cervical cancer were selected as the research object,and the expression of Occludin in 40 couples of cancer tissue and normal tissue were measured by Western Blotting.The correlation between expression of Occludin protein and clinical characteristics was analyzed.Results In the cancer and normal tissues,the low expression rates of Occludin protein were 62.50％ (25 cases / 40 cases) and 77.50％ (31 cases /40 cases),the high expression rates of Occludin protein were 37.50％ (15 cases / 40 cases) and 22.50％ (9 cases/40 cases),the expression quantity of Occludin protein were (0.39 ± 0.34) and (0.11 ± 0.11),the differences were statistically significant(all P ＜0.05).There was no significant correlation between the level of Occludin expression and patients' age,tumor size,FIGO stage,pathological grading and lymph node metastasis (all P ＞ 0.05).Conclusion Down-regulation of Occludin protein was observed in cervical cancer tissues,which may contribute to the development of cervical cancer.However,it was not correlated with the patients' clinical characteristics.
