Expression level of Stathmin gene in ovarian cancer tissues and its relationship with the sensitivity of paclitaxel and cisplatin
10.13699/j.cnki.1001-6821.2018.07.021
- VernacularTitle:Stathmin基因在卵巢癌组织中的表达水平及其与紫杉醇联合顺铂敏感性的研究
- Author:
Xue-Mei MAO
1
;
Wei ZHENG
;
Lan-Fang LIU
Author Information
1. 浙江大学附属第二医院妇科
- Keywords:
stathmin gene;
ovarian cancer tissues;
sensitivity;
aclitaxel;
cisplatin
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(7):805-808
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore and study the expression level of Stathmin gene in ovarian cancer tissues and its relationship with paclitaxel and cisplatin chemotherapy.Methods The tumor tissues and adjacent normal tissues of 30 cases of patients with primary ovarian cancer were selected as the research group and the control group.The expression level of Stathmin protein was detected by Immunohistochemistry,and sensitivity of ovarian tumor tissues to 0,0.30,3.00,30.00,300.00 mg · L-1 paclitaxel combined with cisplatin was analyzed by Methyl-cyclopentadienyl-Manganese-Tricarbonyl (MMT).The relationship between Stathmin expression in ovarian cancer tissues and the sensitivity of paclitaxel and cisplatin chemotherapy were analyzed.Results The positive rates of Stathmin gene in the treatment group and control group were respectively 53.33％ and 10.00％,and the difference was significantly different (P ＜ 0.05).The rates of hypersensitivity,medium sensitivity and insensitivity were 30.00％,50.00％ and 20.00％in the 0.30 mg · L-1 group,43.33％,40.00％ and 16.67％ in the 3.00 mg · L-1 group,56.67％,26.67％ and 16.67％ in the 30.00 mg· L-1 group,20.00％,16.67％,63.33％ in the 300.00 mg · L-1 group.There were significant differences in hypersensitivity and insensitivity between the 30.00 mg · L-1 group and the 300.00 mg · L-1 group (all P ＜ 0.05).There were significant differences in medium sensitivity and insensitivity between the 300.00 mg· L-1 group and the 0.30 mg· L-1 group (all P ＜ 0.05).There was significant difference in hypersensitivity between the 30.00 mg · L-1 group and the 0.30 mg · L-1 group (P ＜ 0.05).After treatment with 300.00 mg · L-1 paclitaxel combined with cisplatin,the positive rates of Stathmin gene were 29.41％,62.50％ and 80.00％,and the differences were significantly different (all P ＜ 0.05).Conclusion The expression level of Stathmin in ovarian cancer tissues is significantly higher than that in adjacent normal tissues,whichis related to the sensitivity to paclitaxel and cisplatin.
