Clinical trial of doxorubicin injection in the treatment of post-herpetic neuralgia
10.13699/j.cnki.1001-6821.2018.07.011
- VernacularTitle:多柔吡星注射剂治疗带状疱疹后遗神经痛的临床研究
- Author:
Yi-Xiong WANG
1
;
Bao-Zhu XU
;
Jing-Jia YAN
;
Chang-Cheng JIANG
;
Yuan-Zhao ZHUANG
;
Jian-Ying ZHOU
Author Information
1. 福建医科大学附属泉州第一医院麻醉科
- Keywords:
doxorubicin injection;
post-herpetic neuralgia;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(7):774-776
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of doxorubicin injection in the treatment of post-herpetic neuralgia.Methods One hundred and four patients with post-herpetic neuralgia were randomly divided into control and treatment groups with 52 cases per group.Control group was given pulse radiofrequency therapy with 3 min per time,twice a week.Treatment group was given doxorubicin 10 mg per time,once two weeks,intervertebral foramen injection.Two groups were treated for 4 weeks.The clinical efficacy,visual analogue scale (VAS) scores,the levels of serum interleukin-6 (IL-6) and IL-10,and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 86.54％ (45 cases/52 cases) and 69.23％ (36 cases/52 cases) with significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:IL-6 were (174.83±23.72) and (321.65 ±45.82) pg · mL-1,IL-10 were (183.46 ±28.11) and (164.67 ±21.31) μg · mL-1,VAS were (2.32 ±0.65) and (3.51 ±0.84) score,the differences were statistically significant (all P ＜ 0.05).The adverse drug reactions in treatment group were skin numbness in block area and palpitation,and no adverse drug reactions occurred in control group.The incidences of adverse drug reactions in treatment and control groups were 5.77％ and 0 without significant difference (P ＞ 0.05).Conclusion Doxorubicin injection has a definitive clinical efficacy in the treatment of post-herpetic neuralgia,which can significantly balance the inflammatory factors,improve the pain,without increasing the incidence of adverse drug reactions.
