Clinical trial of salviae miltiorrhizae and ligustrazine hydrochloride injection combined with atorvastatin calcium tablets in the treatment of senile hypertension
10.13699/j.cnki.1001-6821.2018.07.007
- VernacularTitle:丹参川芎嗪注射液联合阿托伐他汀钙片治疗老年高血压的临床研究
- Author:
Yu-Zhen WANG
1
;
Shi-Yao WANG
;
Xiu-Yan WANG
Author Information
1. 开滦总医院干部病房
- Keywords:
salviae miltiorrhizae and ligustrazine hydrochloride injection;
atorvastatin calcium tablet;
senile hypertension;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(7):760-762
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of salviae miltiorrhizae and ligustrazine hydrochloride injection combined with atorvastatin calcium tablets in the treatment of senile hypertension.Methods Ninety-six elderly patients with hypertension were randomly divided into control and treatment groups with 48 cases per group.Control group was treated with atorvastatin calcium 20 mg per time,qd,orally.Treatment group was given salviae mihiorrhizae and ligustrazine hydrochloride injection 10 mL per time,qd,intravenous drip,on the basis of control group.Two groups were treated for 2 weeks.Then clinical efficacy and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 85.42％ (41 cases / 48 cases) and 66.67％ (32 cases /48 cases) with significant difference (P ＜ 0.05).The adverse drug reactions of treatment group were dizziness and gastrointestinal discomfort,which in control group were gastrointestinal discomfort and elevated alanine transaminase.The incidences of adverse drug reactions in treatment and control groups were 6.25％ and 8.33％ without significant difference (P ＞0.05).Conclusion Salviae miltiorrhizae and ligustrazine hydrochloride injection combined with atorvastatin calcium tablets has a definitve clinical efficacy and safety in treatment of senile hypertension.
