Clinical trial of naloxone injection combined with bumetanide injection in the treatment of cerebral edema after acute cerebral infarction
10.13699/j.cnki.1001-6821.2018.07.003
- VernacularTitle:纳洛酮注射液联合布美他尼注射液治疗急性脑梗死后脑水肿的临床研究
- Author:
Li-Hua ZHANG
1
;
Tie-Lin ZHANG
;
Jing-Guo ZHANG
Author Information
1. 河北大学附属医院急诊医学科
- Keywords:
naloxone injection;
bumetanide injection;
acute cerebral infarction;
brain edema;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(7):747-749
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of naloxone injection combined with bumetanide injection in the treatment of cerebral edema after acute cerebral infarction.Methods Eighty-two patients with cerebral edema after acute cerebral infarction were randomly divided into control and treatment groups with 41 cases per group.Control group was treated with 20％ mannitol injection100 mL per time,qd,intravenous drip,continuous use for 7-10 days.Treatment group was treated with naloxone 4 mg per time,qd,intravenous drip,continuous use for 14 d + bumetanil 2 mg per time,qd,intravenous injection,continuous use for 7-10 days,on the basis of control group.The clinical efficacy,S-100β,neuronal specific enolase (NSE),myelin basic protein (MBP),cerebral edema volume and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 95.12％ (39 cases/41 cases) and 75.61％ (31 cases/41 cases) with significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:S-100β were(0.42 ± 0.05) and (0.54 ± 0.07) μg · L-1,NSE were (9.48 ± 1.29) and (12.73 ± 1.62)μg · L-1,MBP were (1.43 ± 0.17) and (1.72 ± 0.28)μg · L-1,cerebral edema volume were (20.31 ± 2.52) and (24.53 ± 3.15) mL,the differences were statistically significant (all P ＜ 0.05).The adverse drug reactions of two groups were electrolyte disorders and urinalysis.The total incidences of adverse drug reactions in treatment and control groups were 12.20％ and 17.07％ without significant difference (P ＞ 0.05).Conclusion Naloxone injection combined with bumetanide injection has a definitive clinical efficacy in the treatment of cerebral edema after acute cerebral infarction,which can significantly reduce the Levels of S-100β,NSE and MBP,without increasing the incidence of adverse drug reactions.
