Clinical trial of β-aescin sodium injection combined with bumetanide injection in the treatment of acute cerebral infarction with cerebral edema
10.13699/j.cnki.1001-6821.2018.07.002
- VernacularTitle:β七叶皂苷钠注射液联合布美他尼注射液治疗急性脑梗死伴脑水肿的临床研究
- Author:
Wen WEN
1
;
Yan CHEN
;
Tian-Jin LING
;
Hai-Zhi GUO
;
Tian-Lin ZHANG
;
Neng-Wei YU
Author Information
1. 资阳市第一人民医院/四川大学华西医院资阳医院神经内科
- Keywords:
β-aescinate injection;
bumetanide injection;
acute cerebral infarction;
cerebral edema;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(7):744-746,766
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of β-aescin sodium injection combined with bumetanide injection in the treatment of acute cerebral infarction with cerebral edema.Methods Ninety -eight patients of acute cerebral infarction with cerebral edema were randomly divided into control and treatment groups with 49 cases per group.Control group was given 20％ mannitol injection 250 mL per time,qd,intravenous infusion.Treatment group was treated with β-aescin sodium injection 20 mg per time,qd,intravenous infusion + bumetanide injection 2 mg per time,qd,intravenous injection,on the basis of control group.Two groups were treated for 7-10 days.The clinical efficacy,superoxide dismutase (SOD),interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α) and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 85.71％ (42 cases/49 cases) and 67.35 ％ (33 cases/49 cases) with significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:SOD were (64.71 ± 8.19) and (59.65 ± 8.52) kU · L-1,IL-6 were (54.03±7.53) and (65.49±6.93)ng· L-1,TNF-α were (8.59:±0.89) and (9.54 ±l.00)ng· L-1,the differences were statistically significant (all P ＜ 0.05).The adverse drug reactions in treatment group were hyperglycemia,electrolyte disorder and urinalysis abnormality,which in control group were electrolyte disorder and urinalysis abnormality.The total incidences of adverse drug reactions in treatment and control groups were 14.29％ and 12.24％ without significant difference (P ＞0.05).Conclusion β-aescin sodium injection combined with bumetanide injection has a definitive clinical efficacy in the treatment of acute cerebral infarction with cerebral edema,which can effectively improve the level of oxidative stress and inflammatory factors,without increasing the incidence of adverse drug reactions.
