Clinical trial of butylphthalide injection combined with atorvastatin tablets in the treatment of patients with cerebral infarction
10.13699/j.cnki.1001-6821.2018.07.001
- VernacularTitle:丁苯酞注射液联合阿托伐他汀片治疗脑梗死患者的临床研究
- Author:
Li-Feng LIN
1
;
Zhou LIU
;
Wei LIANG
;
Wen-Chuan XIAN
;
Feng LIAO
Author Information
1. 广东医科大学附属医院神经内科
- Keywords:
butylphthalide injection;
atorvastatin tablet;
cerebral infarction;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(7):741-743
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of butylphthalide injection combined with atorvastatin tablets in the treatment of patients with cerebral infarction.Methods A total of 100 patients with cerebral infarction were randomly divided into control group (n =48 cases) and treatment group (n =52 cases).Control group was treated with aspirin enteric-coated tablets 200 mg + atorvastatin 10 mg,orally,Ginkgo leaf extract and dipyridamole injection 20 mL intravenous drip,qd.Treatment group was treated with butylphthalide injection 100 mL on the basis of control group,intravenous drip,2 times a day.All patients were treated for 20 d.The levels of low density lipoprotein (LDL),fasting blood glucose,2 h postprandial blood glucose,fibrinogen,platelet count,National Institute of Health stroke scale (NIHSS),Barthel index and adverse drug reactions were compared between the two groups.Results After treatment,the total effective rates of treatment group and control group were 92.31％ (45 cases/52 cases),75.00％ (36 cases/48 cases),with significant difference (P ＜ 0.05).After treatment,the 2 h postprandial blood glucose in treatment group and control group were (7.30 ± 0.61),(7.05 ± 0.48) mmol · L-1,fibrinogen were (3.55 ± 0.14),(3.45 ± 0.11) g · L-1,low density lipoprotein were (2.67 ± 0.42),(3.13 ± 0.41) mmol · L-1,fasting blood glucose were (4.69±0.31),(5.12±0.50) mmol·L-1,platelet count were (211.14±7.71) ×109/L,(221.23 ±7.81) × 109/L,all with significant difference (all P ＜ 0.05).After treatment,the NIHSS scores of treatment group and control group were 8.28 ± 2.36,13.50 ± 4.24,Barthel index were 73.67 ± 11.32,57.91 ± 9.87,all with significant difference (all P ＜0.05).The incidence of adverse drug reactions in treatment group and control group were 9.62％ (5 cases/52 cases) and 6.25％ (3 cases/48 cases),with no significant difference (P ＜ 0.05).Conclusion Butylphthalide combined with atorvastatin calcium tablets in the treatment of patients with cerebral infarction had significant clinical effect,with high safety.
