Evaluation of the predictive performance for a vancomycin population pharmacokinetic model
10.13699/j.cnki.1001-6821.2018.06.029
- VernacularTitle:万古霉素群体药代动力学模型在临床应用中的预测性能的评估
- Author:
Hui-Mei PANG
1
;
Tao-Tao LIU
;
Wen-Xing WEI
;
Xiao-Ling QIN
;
Li JING
;
Qing GUO
;
Hua LU
;
Dao-Hai CHENG
Author Information
1. 广西医科大学第一附属医院药学部
- Keywords:
vancomycin;
population pharmacokinetic model;
predictive performance;
clinical application
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(6):710-712,724
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the predictive performance of a vancomycin population pharmacokinetic (PPK) model in clinical application.Methods Adult inpatients who received intravenous vancomycin treatment were collected in the First Affiliated Hospital of Guangxi Medical University.Individual predictive values (IPRED) of steady-state trough concentrations (Ctrough) and peak concentrations (Cpeak) at a given dose were estimated by bayesian feedback method basing on a PPK model.The predictive performance was evaluated by comparing the IPRED with the measured values.Results A total of 271 patients with 697 samples were included,including 417 Ctrough and 280 Cpeak.The mean Ctrough and its mean IPRED were (11.85 ±7.14) and (11.08 ±6.81)mg · L-1;the mean Cpeak and its mean IPRED were (18.42 ±9.61) and (17.61 ±7.37) mg · L-1.The mean error,mean relative error,mean absolute error and root mean square error were-0.77 mg · L-1,-2.53％,1.63 mg · L-1 and 2.38 mg · L-1 for Ctrough,and-0.81 mg · L-1,1.53％,2.28 mg · L-1 and 3.32 mg · L-1 for Cpeak,respectively.About 92％ of the concentrations had a relative error within ± 30％.Conclusion Previously established vancomycin PPK model has an excellent predictive performance in the clinical application,which is useful for individualized administration of vancomycin in adult patients.
