Establishment and validation of vancomycin population pharmacokinetic model for intensive care unit patients
10.13699/j.cnki.1001-6821.2018.06.014
- VernacularTitle:万古霉素在重症监护患者的群体药代动力学模型建立与验证
- Author:
Ping YANG
1
;
Ya-Ou LIU
;
Zheng-Yuan SHI
;
Dan YAN
;
Wei LU
Author Information
1. 首都医科大学附属北京世纪坛医院药剂科
- Keywords:
vancomycin;
intensive care unit patients;
population pharmacokinetic model;
model validation
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(6):656-659
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the population pharmacokinetic (PPK) model of vancomycin in intensive care unit (ICU) patients,for guiding the adjustment of dosage regimen.Methods A total of 112 routine blood vancomycin concentration monitoring data were collected from 54 cases of ICU patients.A nonlinear mixed effect modeling pro gram was used to establish one-compartment model with NONMEM soft ware.Internal model validation by goodness-of-fit and bootstrap were performed to evaluate the robustness and prediction of the final model.Ninety-five routine blood vancomycin concentration monitoring data was collected from 35 cases of ICU patients,and the external validation of the model was performed by goodness-of-fit parameter method.Results The results of internal and external validation of the model showed that the model was stable and could predict the dynamic variation of vancomycin concentration well.Conclusion The in vivo process of vancomycin after intravenous administration in ICU patients was consistent with the single-compartment PPK model.The clearance of vancomycin was significantly influenced by meropenem.
