Effect of interventional chemotherapy on angiogenesis and apoptotic protein expression in pathological tissues of patients with lung cancer
10.13699/j.cnki.1001-6821.2018.06.006
- VernacularTitle:介入化疗对肺癌患者术后病理组织血管生成和凋亡蛋白表达的影响
- Author:
Xue-Song ZHANG
1
;
Kui-Yang WANG
;
Li-Ju WANG
;
Lei SONG
Author Information
1. 大连医科大学附属第二医院介入科
- Keywords:
lung cancer;
interventional chemotherapy;
angiogenesis;
apoptosis
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(6):629-631
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of interventional chemotherapy on angiogenesis and apoptotic protein expression in pathological tissues of patients with lung cancer.Methods Ninety-four lung cancer patients were divided into control group and treatment group,47 cases in each group.The patients in two groups were treated with lung cancer resection.In control group,no chemotherapy was given preoperatively.The treatment group was given adriamycin combined with cisplatin before chemotherapy.The expression of angiogenesis related factors and microvessel density (MVD) were compared between the two groups.The expressions of survivin and p53 in two groups were detected.Results The positive rates of vascular endothelial growth factor (VEGF) expression in control group and treatment group were 51.06％ and 23.40％,the positive rates of Sema3 protein were 4.26％,25.53％ and microvessel density were 23.17 ± 2.45 and 10.16 ± 2.05,all with significant difference (all P ＜ 0.01).The relative expression of puma protein in control group and treament group were 0.87± 0.01 and 1.11 ± 0.01,and the relative expression of survivin protein were 1.55 ± 0.02 and 0.56 ± 0.01,all with significant difference (all P ＜ 0.01).Conclusion The mechanism of preoperative chemotherapy may be related to inhibition of angiogenesis,up-regulation of the expression of proapoptotic protein puma and down-regulation of survivin expression of anti-apoptotic protein.
