Clinical trial of sodium aescinate injection combined with nicardipine hydrochloride injection in the treatment of patients with hypertensive intracerebral hemorrhage
10.13699/j.cnki.1001-6821.2018.06.003
- VernacularTitle:注射用七叶皂苷钠联合盐酸尼卡地平注射液治疗高血压脑出血患者的临床研究
- Author:
Ze-Bo FANG
1
;
Yu-Qing HOU
;
Jin-Guo XIE
Author Information
1. 南方医科大学南方医院药材科
- Keywords:
β-sodium aescinate for injection;
nicardipine;
hypertension;
cerebral hemorrhage
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(6):618-621
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effect of sodium aescinate injection combined with nicardipine hydrochloride injection in the treatment of patients with hypertensive intracerebral hemorrhage.Methods Eight-six patients with hypertensive intracerebral hemorrhage were randomly divided into control group (n =43) and treatment group (n =43).Control group was treated with nicardipine hydrochloride injection 0.5-5 μg · min-1 · kg-1.Patients in treatment group were treated with sodium aescinate injection 10 mg on the basis of control group,qd,intravenous infusion.Residual blood volume,volume of cerebral edema,serum calcium,serum creatinine,levels of aquaporin (AQP),Hasegawa dementia scale,National Institute of Health Stroke Scale (NIHSS) score,Barthel score and adverse drug reactions were compared between the two groups.Results Mter treatment,the residual blood volume and brain edema volume in treatment group were (6.36 ± 0.65) and (11.54 ± 1.36) mL,had significant difference with those in control group,which were (10.08 ± 1.33) and (17.22 ± 1.15) mL (all P ＜ 0.05).The levels of serum calcium in treatment group and control group were (3.15 ±0.42),(2.14 ±0.22) mmol· L-1,with significant difference (P ＜0.05).The serum total creatinine and AQP-1 and AQP-4 levels in treatment group were (62.77 ± 6.67) μmol · L-1,(3.07 ± 0.38)μg·mL-1,(43.17 ± 4.83) μg · mL-1,had significant difference with those in control group,which were (73.76 ± 8.03) μmol · L-1,(5.94 ± 0.54) μg · mL-1 and (82.08 ± 5.92) μg · mL-1 (all P ＜ 0.05).The Hasegawa dementia scale,Barthel score and NIHSS in treatment group were 36.11 ±3.44,93.16 ±0.71,6.34 ±0.77,had significant difference with those in control group,which were 28.75 ±3.02,81.65 ± 1.58,11.58 ± 1.51 (all P ＜ 0.05).In treatment group,there were 1 case of rash,1 case of cough,2 cases of digestive tract reaction and 2 cases of acute renal injury,with the incidence of 13.95％ (6 case/43 case).In control group,there were 2 cases of rash,2 cases of cough,1 case of gastrointestinal reaction and 3 cases of acute renal injury,with the incidence of 18.60％ (8 cases/43 cases).There was no significant difference in the incidence of adverse drug reactions between the two groups (P ＞ 0.05).Conclusion The clinical efficacy of sodium aescinate injection combined with nicardipine hydrochloride injection in the treatment of patients with hypertensive intracerebral hemorrhage is great,and can effectively improve the patients' blood calcium,blood creatinine and AQP levels.
