Risk factors associated with clopidogrel resistance in type 2 diabetes mellitus patients with cerebral infarction
10.13699/j.cnki.1001-6821.2018.05.010
- VernacularTitle:2型糖尿病合并脑梗死患者发生氯吡格雷抵抗的危险因素研究
- Author:
Jun-Wei LIU
1
;
Hong-Mei LI
;
Ai-Ming DENG
Author Information
1. 广州军区广州总医院 内分泌科
- Keywords:
type 2 diabetes mellitus and cerebral infarction;
clopidogrel resistance;
National institute of health stroke scale
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(5):521-523
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors of clopidogrel resistance in type 2 diabetes mellitus and cerebral infarction patients.Methods A total of 112 patients were divided into treatment group (clopidogrel resistant group,n =25) and control group (clopidogrel non-resistant group,n =87) according to the platelet aggregation.All the patients were taken clopidogrel 75 mg daily at least 7 d.The general data of the patients were recorded.The National institute of health stroke scale (NIHSS) and Alberta stroke program early computed tomography (ASPECT) score were recorded in two groups.The platelet aggregation function were analyzed by adenosine diphosphate (ADP) induced optical turbid metric method and analyze their correlation.Results The NIHSS in treatment group and control group were (3.91 ± 4.95),(2.40 ± 2.09) point,the ASPECT score in treatment group and control group were (11.57 ±6.05),(13.40 ± 1.29) point,with significant difference (P ＜ 0.05).Conclusion Clopidogrel resistance is associated with increased clinical severity and infarct volume in type 2 diabetes mellitus and cerebral infarction patients.
