Current situation of endoplasmic reticulum stress related autophagy and myocardial ischemia/reperfusion injury
10.13699/j.cnki.1001-6821.2018.03.060
- VernacularTitle:内质网应激相关细胞自噬与心肌缺血再灌注损伤的研究现状
- Author:
You WANG
1
;
Su-Hong ZHU
;
Bai-Liu YA
;
Xiu-Hua LIU
Author Information
1. 济宁医学院基础医学院
- Keywords:
endoplasmic reticulum stress;
autophagy;
myocardium;
ischemia/reperfusion injury
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(3):382-386
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a cellular degradation process for long-lived proteins and unnecessary or damaged organelles.The endoplasmic reticulum stress (ERS) response represents an adaptive mechanism that triggers the unfolded protein response to maintain ER homeostasis.Both ERS and autophagy were like double-edged sword,by which appropriate activity is cell protective,but excessive degree will trigger cell death.Several studies have suggested that ERS induced autophagy,which played the important role in myocardial ischemia reperfusion injury.This article reviews the recent advances about the effects and possible mechanism of ERS related autophagy on myocardial ischemia reperfusion injury.
