Correlation between allergic reaction of anti-tuberculosis drugs and human leukocyte antigen-DRB gene polymorphism
10.13699/j.cnki.1001-6821.2018.03.025
- VernacularTitle:抗结核药过敏反应与人类白细胞抗原-DRB基因多态性的相关性
- Author:
Yu LIU
1
;
Fa-You YANG
;
Xiao-Lan YUAN
;
Yu XU
;
Chun-Hua XIA
;
Guo-Fang DENG
Author Information
1. 南昌大学临床药理研究所
- Keywords:
tuberculosis;
allergic reaction;
sequence-specific primer-polymerase chain reaction;
human leukocyte antigen
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(3):272-274
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between human leukocyte antigen (HLA) DRB gene polymorphism and allergic reaction of anti-tuberculosis drugs in Chinese Han population.Methods HLA-DRB alleles in 35 patients with allergic reaction and 42 patients with no allergic reaction were analyzed using sequence-specific primer-polymerase chain reaction (PCR-SSP) method.Results The frequency of DR7 gene in allergy group was significantly higher than that in patients without allergic reaction group (10.0％ vs 1.2％,RR =10.25,P ＜0.05).Conclusion DR7 may be a susceptible gene for allergic reactions to anti-tuberculosis drugs.
