Clinical trial of tinidazole tablets combined with minocycline hydrochloride ointment in the treatment of chronic periodontitis
10.13699/j.cnki.1001-6821.2018.03.017
- VernacularTitle:替硝唑片联合盐酸米诺环素软膏治疗慢性牙周炎的临床研究
- Author:
Ze-Biao ZHANG
1
;
Ying ZHANG
;
Wan-Ling HUANG
;
Yan-Ru CHEN
Author Information
1. 福建医科大学附属泉州第一医院口腔科
- Keywords:
tinidazole tablet;
minocycline hydrochloride ointment;
chronic periodontitis;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(3):248-250
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of tinidazole tablets combined with minocycline hydrochloride ointment in the treatment of chronic periodontitis.Methods Ninety-four patients with chronic periodontitis were randomly divided into control and treatment groups with 47 cases per group.Control group was filled with minocycline hydrochloride ointment in the periodontal pocket,once a week.Treatment group was treated with tnidazole 250 mg per time,qd,orally,on the basis of control group.Two groups were treated for 4 weeks.The clinical efficacy,levels of soluble intercellular adhesion molecule 1 (slCAM-1),interleukin-1 β (IL-11) in gingivil,monocyte chemoattractant protein -1 (MCP-1) and adverse drug reactions were compared between two groups.Results After treatment,total effective rates of treatment and control groups were 95.74％ (45 cases / 47 cases) and 80.85％ (38 cases / 47 cases) with significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:sICAM-1 were (87.64 ± 11.20) and (99.87 ± 14.52) μg · L-1,IL-1β were (25.66 ±4.21) and (34.81 ±4.16) μg · L-1,MCP-1 were (28.11 ±4.65) and (39.36 ±3.66) ng · L-1,the differences were statistically significant(all P ＜0.05).The adverse drug reactions of two groups were low blood pressure and headache.The total incidences of adverse drug reactions in treatment and control groups were 12.77％ and 14.89％ without significant difference (P ＞ 0.05).Conclusion Tinidazole tablets combined with minocycline hydrochloride ointment have a definitive clinical efficacy in the treatment of chronic periodontitis,which can significantly reduce the levels sICAM-1,IL-1β and MCP-1,without increasing the incidence of adverse drug reactions.
