Clinical trial of ozagrel sodium injection combined with mild hypothermia in the treatment of craniocerebral injury acute cerebral infarction
10.13699/j.cnki.1001-6821.2018.03.004
- VernacularTitle:奥扎格雷钠注射液联合亚低温治疗颅脑外伤急性脑梗死的临床研究
- Author:
Song-Fang CHEN
1
;
Ming ZOU
;
Zhi-Yong HE
;
Bei-Lei HU
;
Xian-Yang GUO
;
Han-Song SHENG
Author Information
1. 温州医科大学附属第二医院神经内科
- Keywords:
ozagrel sodium injection;
mild hypothermia;
craniocerebral injury;
acute cerebral infarction;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(3):206-208
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of ozagrel sodium injection combined with mild hypothermia in the treatment of craniocerebral injury acute cerebral infarction.Methods Sixty-two patients of craniocerebral injury acute cerebral infarction were randomly divided into control group (n =31 cases) and treatment group (n =31 cases).Control group was given Xueshuantong injection 10 mL qd,intravenous drip.Treatment group was taken with ozagrel sodium 100 mL bid,intravenous drip,and mild hypothermia treatment.Two groups were treated for 14 d.The clinical efficacy,national institutes of health stroke scale (NIHSS) scores,Barthel index (BI),changes of hemodynamic indexes and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in treatment and control groups were 90.32％ (28 cases/31 cases) and 61.29％ (19 cases/ 31 cases) with significant difference (P ＜0.05).After treatment,the main indexes in treatment and control groups were compared:NIHSS scores were (8.24 ± 0.76),(15.42 ± 1.65) points;BI were (75.23 ± 3.48),(52.32 ± 3.33) points;whole blood high shear viscosity respectively were (3.46 ±0.21),(4.63 ±0.26) mPa · s;whole blood low shear viscosity were (7.69 ±0.32),(8.38 ±0.31) mPa · s;plasma viscosity were (1.24 ±0.11),(1.76 ±0.16) mPa · s;fibrinogen were (3.07 ±0.41),(4.16 ±0.18)g · L-1,there were statistically significant differences (all P ＜0.05).No adverse drug reactions were observed during the treatment in two groups.Conclusion Ozagrel sodium injection combined with mild hypothermia has a definitive clinical efficacy and safety in the treatment of craniocerebral injury acute cerebral infarction,which can improve the patient's hemodynamic parameters,neurological function and activities of daily living.
