Clinical trial of methylprednisolone sodium succinate injection in the treatment of patients with respiratory distress syndrome
10.13699/j.cnki.1001-6821.2018.03.001
- VernacularTitle:甲泼尼龙琥珀酸钠注射剂治疗呼吸窘迫综合征的临床研究
- Author:
Jie ZHANG
1
;
Tian-Tian SONG
;
Shi-Yuan ZHAO
;
Huai-Xin WANG
;
Xue ZHU
Author Information
1. 潍坊市益都中心医院急诊科
- Keywords:
methylprednisolone sodium succinate injection;
respiratory distress syndrome;
oxygenation index;
serum biochemical index
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(3):197-199
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of methylprednisolone sodium succinate on oxygen indexes (PaO2/FiO2) and serum biochemical indexes in patients with respiratory distress syndrome.Methods Seventy-two patients with respiratory distress syndrome were randomly divided into treatment group and control group,36 cases in each group.Control group was given routine treatment.Treatment group was given methylprednisolone sodium succinate 120 mg · d-1,by intravenous drip on the basis of control group.All the patients were treated continuously for two weeks.The PaO2/FiO2 and acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) scores before and after treatment were observed.The levels of nitric oxide (NO),interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α),C-reactive protein (CRP) and adverse drug reactions in two groups were observed.Results After treatment,the PaO2/FiO2 levels in treatment group and control were (287.62 ±24.57),(213.21 ±25.67)mmHg,the APACHE Ⅱ scores were 11.23 ± 1.66,15.59 ± 2.21,all with significant difference (all P ＜ 0.05).The levels of NO were (58.88±32.76) and (74.28 ±32.94) μ mol· L-1,the levels of IL-6 were (167.94 ±25.29) and (213.11±21.50) pg· mL-1,the levels of TNF-α were (22.35 ±8.93) and (36.30±9.88) pg·mL-1,the levels of CRP were (6.43 ± 3.02) and (9.25 ± 2.94) mg · L-1,all with significant differences (all P ＜ 0.05).There were 2 cases of short-term elevated blood pressure in treatment group,and there was no adverse drug reaction in control group,without significant difference (P ＞ O.05).Conclusion Methylprednisolone sodium succinate in the treatment of respiratory distress syndrome can significantly improve the PaO2/FiO2,reduce the APACHE Ⅱ score and serum biochemical indicators,and can improve the clinical effect with high safety.
