Review of the efficacy and safety of subconjunctival injection of aminoglycoside antimicrobials
10.13699/j.cnki.1001-6821.2018.02.022
- VernacularTitle:结膜下注射氨基糖苷类抗菌药物的有效性和安全性评价
- Author:
An-Na LI
1
;
Ting-Ting QIU
;
Chao ZHANG
Author Information
1. 北京大学第三医院药剂科
- Keywords:
subconjunctival injection;
aminoglycoside;
efficacy;
safety;
systematic review
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(2):173-176,180
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the efficacy and safety of aminoglycoside antibiotics in the treatment of ocular infection through subconjunctival injection.Methods PubMed,EmBase,Cochrane library,Wanfang and CNKI databases were searched from inception until March 2017 to investigate clinical trials about subconjunctival injection of aminoglycoside antimicrobials for the treatment of eye infection.Systematic evaluation was used to analyze the main indexes such as the cure rate of eye infection,the drug concentration in aqueous humor,the occurrence of eye pain after injection and the incidence of conjunctival edema.Results A total of 18 randomized controlled trials were enrolled in our study.The results showed that the cure rate of eye infection through subconjunctival injection of aminoglycoside antibiotics was excellent and an adequate aqueous humor concentration could be attained.No systemic toxicity was found,but the incidences of eye pain (39.62％) and conjunctival edema (72.58％) were high.Conclusion Subconjunctival injection of aminoglycoside antibiotics was effective.Considering the low quality of included studies,the safety of subconjunctival injection of aminoglycoside antibiotics needs to be further verified.
