Evaluating the effect of reducing blood lipid in different parts of Rheum palmatum L. with Fuzzy matter-element model based on variation coefficient weight
10.13699/j.cnki.1001-6821.2018.02.021
- VernacularTitle:基于变异系数权重的模糊物元模型评价大黄不同提取部位降血脂的效果
- Author:
Rui-Jing YANG
1
;
Jia-Hui GU
;
Shun-Juan ZHU
;
Shao-Hong LI
;
Peng-Fei XIA
;
Lei ZHAO
Author Information
1. 甘肃中医药大学药学院
- Keywords:
Rheum palmatum L.;
reduce blood lipid;
fuzzy matter-element model;
variation coefficient weight
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(2):169-172
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of reducing blood lipid in three effective parts of Rheum palmatum L.based on variation coefficient weight.Methods First of all,the SD rat model of hyperlipidemia was given the water extract,the ethanol extract and the ethyl acetate extract of Rheum palmatum L.,then the content of total cholesterol (TC),high densitylipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C),triglyceride (TG) in serum were determined and general survival of rats was analyzed.Then using fuzzy matter-element model on variation coefficient weight to evaluate the comprehensive reducing blood lipid effect of different extract parts of Rheum palmatum L..In the end,combining with the result of the value of Euclid approach degree,compared the effect of normal group (M1),the model group (M2),the positive control group (Xuezhikang,M3),the water extract group(M4),the ethanol extract group (M5),the ethyl acetate extract group (M6) of blood lipid.Results Compared with model group,the water extract part and the ethanol extract part of Rheum palmatum L.could reduce the congtents of TC,LDL-C,TG and rise HDL-C.Combining with the result of the value of Euclid approach degree,the water extract was 0.74,the ethanol extract was 0.54.Combining with the result of the value of Euclid approach degree,the order of its magniude is M3 ＞ M4 ＞ M1 ＞ M5 ＞ M6 ＞ M2.Conclusion The water extract part is the effective part of reducing blood lipid.The method and model can be used to objectively evaluate the comprehensive effect of reducing blood lipid of Rheum palmatum L.'s three extracted parts.
