Influential factors of serum concentration/dosage ratio for schizophrenia patients after oral administration of risperidone
10.13699/j.cnki.1001-6821.2018.02.007
- VernacularTitle:利培酮在精神分裂症患者中的血清药物浓度/剂量比影响因素研究
- Author:
Hao-Yang LU
1
;
Xiao-Jia JIANG
;
De-Wei SHANG
;
Xiao-Jia NI
;
Zhan-Zhang WANG
;
Ming ZHANG
;
Jian LI
;
Yu-Guan WEN
Author Information
1. 广州医科大学附属脑科医院、广州市惠爱医院药学部
- Keywords:
risperidone;
concentration/dosage ratio;
influential factor
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(2):117-119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influential factors of serum drug concentration/dosage ratio (C/D) for schizophrenia patients after oral administration of risperidone.Methods Medical records of inpatients who received oral administration of risperidone in Guangzhou Huiai Hospital during 2016 were consulted and the C/Ds were calculated.Effects of age,gender,dosage form,combined medication,comorbidity and serum concentration ratio of 9-OH risperidone and risperidone were evaluated.Results C/D in patients aged 60 or older was (10.06 ± 6.61) ng · mL-1 · mg-1 · d.It was significantly larger than those under 60 years old,which were (7.82 ± 3.31) and (8.02 ±4.05) ng · mL-1 · mg-1 · d for 40-59 and under 40 years old,respectively.In addition,C/D was decreased with the increase of 9-OH risperidone/ risperidone ratio.The C/D were(10.96 ±6.46),(8.71 ±4.45)and (6.30 ± 2.99) ng · mL-1 · mg-1 · d for 9-OH risperidone/risperidone ratio ＜ 1,1-10 and ＞ 10,respectively.Gender,dosage form andthe major combined medications and comorbidities in the recruited patients hardly affected the C/D of oral risperidone.Conclusion The dose of risperidone that administered to the aged should be reduced properly.Serum concentration ratio of 9-OH risperidone and risperidonehas a potential to be used as an indirect index of the activity of metabolic enzymes.
