Clinical trial of tenofovir combined with polyethylene glycol interferon α 2a injection in the treatment of drug resistance patients with chronic hepatitis
10.13699/j.cnki.1001-6821.2018.02.004
- VernacularTitle:替诺福韦联合聚乙二醇干扰素α2a注射液治疗耐药慢性乙型病毒性肝炎患者的临床研究
- Author:
Zhi-Peng LIN
1
;
Mi-Long SU
;
Zhi-Jun SU
;
Jiang-Fu LIU
;
Yi-Juan ZHENG
Author Information
1. 福建医科大学附属泉州第一医院感染科
- Keywords:
chronic hepatitis B;
tenofovir;
polyethylene interferon α2a injection;
alanine aminotransferase;
aspartate aminotransferase
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(2):108-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effect of tenofovir combined with polyethylene glycol interferon α2a injection in the treatment of drug resistance patients with chronic hepatitis.Methods Seventy-six patients with drug-resistant chronic hepatitis were divided into control group and treatment group,38 cases in each group.Control group was treated with tenofovir 300 mg,qd,orally.Treatment group was treated with pegylated interferon α2a injection 180 μg on the basis of control group,1 time per week,subcutaneous injection.All patients were treated for 48 weeks.Clinical effect,serum hepatitis B virus deoxyri bonucleic acid (HBV-DNA),alanine aminotransferase (ALT),aspartate aminotransferase(AST),HBV-DNA negative rate and adverse drug reactions in two group were evaluated.Results After treatment,the total effective rates in treatment group and control group were 86.84％ (33 cases/38 cases) and 65.79％ (25 cases/ 38 cases),the HBV-DNA overcast rates were 73.68％ (28 cases/38 cases) and 50.00％ (19 cases/38 cases),with significant difference (P ＜ 0.05).The serum HBV DNA in treatment group and control group were (2.98 ± 0.35) and(4.13 ± 0.43) log10 copies · mL-1,ALT were (38.97 ± 8.44) and (58.51 ± 8.15) U · L-1,AST were (39.13 ±4.21) and (50.62 ±6.45) U · L-1,with significant difference (P ＜0.05).There were 3 cases of dizziness,5 cases of gastrointestinal reaction in control group,and were 4 cases of abnormal blood system,3 cases of gastrointestinal tract reaction,3 cases of skin abnormalities in treatment group.The incidence of adverse drug reactions in control group and treatment group were 21.05％ (8 cases/38 cases) and 26.32％ (10 cases/38 cases),with no significant difference (P ＞ 0.05).Conclusion The clinial effect of tenofovir combined with polyethylene glycol interferon α2a injection in the treatment of drug resistance patients with chronic hepatitis is better than tenofovir alone,and can reduce the serum HBV-DNA,ALT,AST.
