Research progress of a new pharmacokinetics/pharmacodynamic model based on the theory of mutant selection windows
10.13699/j.cnki.1001-6821.2018.01.024
- VernacularTitle:基于突变选择窗理论的新型药代动力学/药效学模型的研究进展
- Author:
Han ZHANG
1
;
Chang-Qing BAI
;
Wen-Kai NIU
;
Xin YUAN
Author Information
1. 中国人民解放军第307医院呼吸与危重症医学科
- Keywords:
mutant prevention concentration;
mutant selection window;
pharmacokinetics/pharmacodynamics;
clinical medication
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(1):89-91
- CountryChina
- Language:Chinese
-
Abstract:
At present,more attention has been paid to the spread of drug -resistant strains caused by the abuse of antibiotics.Comparing to the old model,the new model of pharmacokinetic / pharmacodynamic (PK/PD) which were based on the theory of mutant prevention concentration (MPC) and mutant selection window (MSW),can effectively prevent the emergence of drug-resistant strains by the way of closing or reducing MSW.In this review,we summarized the basic concept and theory of MSW,MPC as well as its application in guiding the establishment of new PK/PD model,hoping to provide references for the rational use of antibiotics and inhibiting the emergence of drug-resistant mutant strains.
